SVP, Medical Affairs

Posted 8/18/2026 · last confirmed live 8/26/2026

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a SVP of Medical Affairs as part of the Medical Affairs team based in Bridgewater, NJ.  Role Overview Legend Biotech is seeking a Senior Vice President, Medical Affairs to provide enterprise leadership for the Company's global Medical Affairs organization. The Senior Vice President, Medical Affairs is a critical enterprise leadership role with significant impact on the scientific, clinical and external medical strategy for Legend’s approved BCMA CAR-T in multiple myeloma, as well the development of future pipeline programs. This leader will set the overall Medical Affairs vision and strategy, partner closely with collaboration partners, such as Johnson & Johnson, as well as internal cross-functional leaders, and ensure Medical Affairs is positioned as a strategic driver of clinical understanding, external engagement, lifecycle planning, data generation, and future growth.  This role will provide senior leadership across home office and field-based Medical Affairs teams and will be accountable for building the capabilities, structure, and talent needed to support CARVYKTI today and Legend’s expanding pipeline, including future in vivo and emerging therapeutic areas.The SVP, Medical Affairs will report to the President, Carvykti Business Unit, will be a member of Carvykti LT and will be based in Bridgewater, NJ.  Key Responsibilities Define and execute the Medical Affairs vision, strategy, and operating model across CARVYKTI and the broader pipeline. Provide enterprise leadership for lifecycle management, evidence generation, scientific communications, medical launch excellence, and external medical engagement. Partner with R&D, Commercial, Regulatory, Safety, Market Access, and Clinical Development to shape product strategy and maximize portfolio value. Ensure medical insights and scientific expertise influence key business and development decisions. Serve as the senior scientific leader and external ambassador for Medical Affairs. Build and maintain relationships with key opinion leaders (KOLs), academic institutions, professional societies, patient advocacy groups, and healthcare stakeholders. Lead the global evidence-generation, publication, and scientific communication strategy. Promote scientific excellence, patient-centered innovation, compliance, and thought leadership across the organization. Build and lead a high-performing Medical Affairs organization capable of supporting current and future business needs. Develop organizational capabilities across Medical Strategy, Field Medical, Medical Communications, Evidence Generation, Medical Operations, and Medical Excellence. Establish talent, succession, leadership development, and capability-building strategies to strengthen organizational effectiveness and future readiness. Drive a culture of accountability, continuous learning, innovation, and high performance. Serve as a key member of the Carvykti BU leadership team, contributing to enterprise strategy and organizational decision-making. Lead Medical Affairs transformation initiatives, including digital innovation, omnichannel engagement, advanced analytics, and operational excellence. Foster strong collaboration across internal functions, alliance and external partners to drive alignment and execution. Ensure effective governance, resource prioritization, performance management, and delivery against strategic objectives. Operate as an enterprise leader with a global mindset. Influence company strategy through scientific leadership and medical insights. Drive organizational excellence and execution across a highly matrixed environment. Champion innovation, patient centricity, and continuous improvement. Develop future medical leaders and strengthen organizational capability. Promote a culture of accountability, inclusion, innovation, collaboration, and high performance. Requirements MD (preferred), PharmD, PhD, or equivalent advanced scientific degree required; board certification and oncology/hematology experience strongly preferred.  15+ years of progressive leadership experience in Medical Affairs, Clinical Development, or related biopharmaceutical leadership roles.  Significant leadership experience in oncology, hematology, cell therapy, or specialty biopharmaceuticals, including responsibility for global Medical Affairs organizations spanning field medical, scientific communications, publications, evidence generation, and external engagement.  Demonstrated success shaping treatment landscapes, supporting product launches and lifecycle management, building high-performing organizations, and developing capabilities to support current and future portfolio growth.  Experience working effectively across complex global partnerships, matrix organizations, and cross-functional leadership teams. Deep understanding of pharmaceutical development and Medical Affairs, with experience across multiple functions such as Clinical Development, Medical Affairs, Regulatory, Commercial, Safety, Translational Development, or Market Access.  Strong scientific credibility with expertise in medical strategy, evidence generation, scientific communications, external stakeholder engagement, and product lifecycle  management.  Prior experience supporting NDA/BLA submissions, launches, and post-launch lifecycle strategies preferred.  Established relationships within the oncology and hematology community, particularly multiple myeloma and/or cellular therapy, preferred.  Proven ability to influence senior executives, drive alignment across complex stakeholder groups, and lead organizational transformation and capability-building initiatives.  Exceptional communication, leadership, negotiation, change management, and collaboration skills, with a demonstrated ability to deliver results across global, matrixed environments.  Strong business acumen, analytical capability, and ability to translate clinical and scientific insights into impactful medical and business strategies. #Li-JK1 #Li-Hybrid The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles. Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. Pay Range (Base Pay): $389,454 — $511,158 USD Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech. Work Authorization & Employment Eligibility Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates. EEO Statement It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. For information related to our privacy notice, please review:  Legend Biotech Privacy Notice .

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