Senior Research Technician

Posted 4/29/2026 · last confirmed live 8/26/2026

Location : London Reporting to: Executive Director, Translational Research Job Summary Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts. This role is based in the heart of London in the Research facility of our Hammersmith headquarters. The Senior Research Technician will be responsible for oversight and management of technical activities relating to core lentiviral vector production and cell & gene therapy analytical methods for the Department of Translational Research. The role requires a deep expertise in molecular biology with applications to C&GT, with experience of viral vector production and characterisation, and related analytical methods, in order to lead activities for the provision of core technical services for the Translational Research team. Candidates should also have project and staff management experience to direct core technical staff, including scheduling and allocation of core activities, as well as providing line management, guidance, training and mentorship. The role will also include provision of laboratory oversight to support the Translational Research teams activities on ensuring compliance with policies, procedures and best practices for an organised and effective working environment to support and optimise productivity and quality of research. The Senior Research Technician will work closely with Translational Research Leadership to work towards continuous improvements in our core technical activities, research quality, data integrity and laboratory practices. Key Elements and Responsibilities: Senior Research Technician · Senior administrative and laboratory technical role responsible for enabling and optimising daily operations of Orchard’s core technical team to support the strategic goals of the Translational Research team. · Provide line management of Translational Research Core Technical team, including allocation of assignments, training and development of technical staff. · Oversee the coordination and processes of core Molecular Biology, Vector and Analytical activities provided for the Translational Research department, to align vector designs with production requirements, working with dedicated technical staff, and where required contribute directly to the delivery of: · Vector Design & Assembly: Generating and validating novel lentiviral vectors for ex vivo or in vivo therapeutic applications, using expertise in molecular biology, CRISPR, PCR, qPCR, ddPCR, molecular cloning, western blotting, and mammalian cell culture. · Production & Optimization: Producing lentivirus, optimising protocols and improving processes to provide high quality and consistent vector yields. · Analytical Testing: Performing assays to assess viral titer, potency, transduction efficiency and purity, and developing standardized protocols for vector performance. · Core LLV and Analytical Team Leadership: Providing expertise to support technical research staff, troubleshooting, updating protocols, and ensuring regulatory compliance. · Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity. · Lead data integrity checks related to the Core technical teams activities, ensuring ELN records are completed with ALCOA+ principals. · Contribute towards the authoring of nonclinical Reports submitted by the Translational Research team. · Develop and implement lab workflows, SOPs and review Risk Assessments and best practices to support the Core LVV & Analytical teams scientific productivity, and drive continuous improvement activities, to oversee the achievement and maintenance of high-quality robust standards of research. · Participation in Translational Research departmental meetings to share updates related to the Core Technical teams activities and provide updates on emerging and innovative technologies & platforms in C&GT Vector and Analytical methods. · Provide compliance monitoring related to internal policies, guidelines and regulations governing laboratory activities to the Translational Research team. · Act as a primary liaison for the Translational Research Team and Facilities Management Team to foster collaborative relationships between researchers and departments. · Work closely with Benchling ELN Administrators to support continuous development of the ELN platform for Orchard’s R&D activities including oversight of inventory management, data capture and data integrity. · Any other duties allocated which fall within the general area of the position. Requirements Education / Key Competencies · Experienced molecular/ cellular biologist with strong technical background and analytical abilities to support core technical research staff · Being a team player with a 'can-do' attitude and problem-solving skills is a must, with experience of line management · Organization, time and project management, prioritizing and the ability to handle a complex, varied workload · Ability to work efficiently, both independently and as part of a team, with excellent communication, collaboration and influencing skills. · Good computer skills, experience of working with an ELN such as Benchling is highly desirable · Ability to deal diplomatically but firmly with difficult situations. · Ability to operate in a fast-paced, multi-disciplinary industrial environment, with a customer service mindset Qualifications/ Experience · Bachelor’s or Master’s degree in Biology, Life sciences, Biochemistry, Bioengineering, or cell and gene therapy related scientific field, with typically 8+ years of experience in laboratory operations, preferably within biotech or pharma research settings. · Or PhD (or equivalent) in biological sciences or cell and gene therapy related scientific field with experience in laboratory operations, preferably within biotech or pharma research settings. · RECRUITERS All employment offers and CV’s are managed through our Human Resources Department and all candidates are presented through this avenue. Therefore, the Human Resources Department at Orchard Therapeutics requests that recruiters are not to contact Orchard Therapeutics employees directly to present candidates. Complying with this request will be a factor in determining future professional relationships with Orchard Therapeutics. Orchard Therapeutics will not accept unsolicited resumes from any source other than directly from candidates for either current or future positions. Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the recruiter does not create any implied obligation on the part of Orchard Therapeutics.

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