Senior/Research Associate

NewLimit · South San Francisco

Posted 2/9/2026 · last confirmed live 8/26/2026

About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking an Senior/Research Associate with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases. Your role will focus on supporting the development of in vitro assays and pre-clinical models to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our scientists as well as our technology-focused teams to help create the first reprogramming medicines for the vascular tissue. What you'll do In your role as a Senior/Research Associate, you will: Isolate cells from primary tissues to optimize in vitro functional assays Develop pre‑clinical models of age-related dysfunction Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions at scale Support the development of in vivo nucleic acid delivery methods for endothelial cells Analyze and interpret experimental data to drive pre-clinical decision making Requirements Bachelor’s degree in cell biology, molecular biology, biochemistry or a related field with 2‑5 years of relevant industry or academic experience Proficiency in primary mammalian cell culture and animal handling techniques for rodent models Proficiency in flow cytometry techniques Exceptional organizational skills, as demonstrated by detailed record-keeping in a lab notebook and an ability to effectively carry out multiple ongoing projects or experiments Nice to have Experience with isolation and functional characterization of primary cells Experience developing animal models of cell dysfunction and/or injury Experience with FACS and flow cytometry Experience using computational tools to automate routine data analysis (e.g. Python, R, etc.) Benefits NewLimit offers generous benefits to ensure our team can focus on our mission: Health, dental, and vision insurance 401(k) with company match Paid parental leave Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays Meals and snacks on-site   Salary Range: $75,000 to $100,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers    *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.  

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