Sr. Software Engineer, Clinical Software

Posted 8/20/2026 · last confirmed live 8/26/2026

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. Summary: We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment. Onsite: Monday, Tuesday, and Thursday  Responsibilities: Design, develop, test, and maintain software systems and features supporting laboratory operations. Develop and optimize backend services and APIs using Python and/or Java. Implement solutions using a variety of database technologies, including relational and graph databases. Take ownership of deploying and maintaining services in our AWS cloud environment. Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability. Troubleshoot and resolve complex technical issues in development and production environments. Collaborate with cross-functional teams to translate business requirements into robust technical solutions. Qualifications: B.S. degree in Computer Science, Engineering, or a related technical field. 5 years of professional software development experience. Strong proficiency in at least one programming language such as Python or Java. Proven experience building and deploying applications on AWS. Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs. Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts. Excellent problem-solving skills and the ability to work independently on complex tasks. Preferred: Experience with web frameworks like Flask or FastAPI. Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js). Experience in the life sciences, healthcare, or another regulated industry. Familiarity with containerization technologies (e.g., Docker). Exposure to graph databases or NoSQL technologies. What You’ll Gain Opportunity to take ownership of significant features and projects from design to deployment. Deepen your expertise in AWS services and cloud architecture. Gain valuable experience working in a regulated life sciences environment. Clear pathways for career growth into a senior engineering role through mentorship and impactful work. The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered. Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you. Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @ personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community. Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)    #LI-KK1 #LI-Hybrid

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