Senior Medical Science Liaison - Gene Therapy US Medical Affairs, Northeast

Orchard Therapeutics · Boston, MA · Remote

Posted 5/1/2026 · last confirmed live 8/26/2026

Location: Remote, Eastern Territory US Reporting to : Senior Director, Medical Affairs – Americas Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts. Job Summary The Senior Medical Science Liaison (Sr MSL) is a therapeutic and disease area scientific expert for investigational and approved gene therapy clinical programs. They demonstrate leadership in field medical excellence and coaching as well as medical and scientific support with national level strategic planning in the Eastern Territory of the United States. As a field-based member of the medical affairs team, the Sr MSL will be responsible for developing and enhancing professional relationships with external thought leaders involved in all phases of the clinical development process through a fair-balanced and high-value exchange of clinical and scientific information. In addition to these typical MSL responsibilities, the Sr MSL will develop strategy, serve as a team mentor, and lead national level initiatives. This position necessitates professionals exhibiting established personal and scientific credibility and self-awareness, who work well in a collaborative, cross-functional environment with other individuals within broader US and Global organization. Key Responsibilities · Identify, build and maintain collaborative partnerships with healthcare providers (HCP’s) and key external experts such as KOL’s and academic institutions to become a trusted scientific partner. · Provide timely, audience-appropriate information and updates to enhance the understanding of the scientific and medical value of Orchard’s programs. This includes, but is not limited to, collaboration with Market Access, Government Affairs, Diagnostics, Patient Advocacy, Clinical Development etc. · Maintain training records and deliver training updates to ensure all personnel in assigned Qualified Treatment Centers are appropriately trained according to Orchard’s SOPs and the latest Product Manual. · Develop a territory profile including Centers of Excellence, key expertise, newborn screening approaches and leaders, and market access pathways to inform medical strategy and tactical planning in collaboration with our Commercial, Diagnostic, and Patient Advocacy partners. · Gather insights from the field on data, therapeutic area, and competitive intelligence to help inform company strategies and evidence generation plans. · Build thorough operational understanding to ensure excellence in execution balanced with risk management within the boundaries of all governance processes. · Review and oversee Investigator-Sponsored Trial (IST) requests and Early Access Program (EAP) requests throughout the internal review process and any follow up requests for information. · Build effective internal partnerships through communication and collaboration across the organization with individuals from Medical Affairs, Patient Advocacy, Public Affairs, Clinical Development, Clinical Operations, Technical Operations, Market Access, Commercial, etc. · Ensure compliance with internal and external regulatory and legal guidelines. · Maintain clinical, scientific, and technical expertise in therapeutic area. · Develop strategic initiatives to support departmental goals from a field medical excellence perspective · Successfully manage at least two large cross-functional projects with demonstrated leadership and collaboration skills while successfully maintaining geographical responsibilities · Proactively seek out and demonstrate successful peer coaching of other team members · Develop US field resource materials specific to stakeholder group, disease state, and technology. · Provide strategic insights by maintaining expertise in the therapeutic area and related fields to effectively communicate scientific insights and support strategic objectives · Monitor the competitive environment for advances and trends in the therapeutic area, including new treatment management and therapies, competitive products and provide feedback to internal stakeholders on specific initiatives of competitors · Serves as peer leader to mentor and coach new or junior MSLs, supporting onboarding, training, and field excellence Requirements Education / Key Competencies · Advanced Scientific / Healthcare Degree (PhD, PharmD, MD, NP, DVM, CGC or similar preferred; RN, MS, or similar with substantial experience considered) · Minimum of 5 years of experience in a scientific, clinical or MSL role within the biotech or pharmaceutical industry · Extensive experience as an MSL supporting post-approval commercial products in the field · Ability to lead and motivate team members without a direct reporting relationship including coaching and mentoring colleagues · Track record of successfully establishing relationships with health care provider thought leaders and extended clinical care teams to become a preferred point of contact and trusted resource. · Understanding of US government and industry guidelines, regulations, laws, etc., for appropriate and compliant exchange of scientific and clinical information with external stakeholders. · Experience and relevant knowledge in one or more key therapeutic areas: hematopoietic stem cell transplantation, gene therapy, and neurology/genetics (neurometabolic genetics preferred). · Experience in developing and delivering effective scientific educational materials and programs for multistakeholder/multispecialty audiences across disease states. · Strong knowledge and established network with health care providers and industry experts · Fluency in both spoken and written English · Excellent communication and presentation skills to concisely convey complex clinical and scientific information · Effective interpersonal skills and awareness of inward and outward emotional intelligence · Ability to apply technical expertise and solutions to diverse/individualized situations · Experience in achieving results, generating ideas and influencing outcomes through collaboration in a fast-paced environment. · Highly effective in building close working relationships with cross-functional partners · Growth mindset – curious by nature, proactive in keeping abreast of key scientific developments and building understanding of assigned territory · Valid US Driver’s License and clean driving record · Ability to travel frequently (75%), often overnight Salary Range : The anticipated salary for this position will be $190,000 - $240,000. The actual salary offered for this role at commencement of employment may vary based on several factors including but not limited to relevant experience, skill set, qualifications, education (including applicable licenses and certifications), job-based knowledge, location, and other business and organizational needs. The company may ultimately pay more or less than the posted range. The listed salary is just one component of the overall compensation package. At Orchard Therapeutics North America we provide a comprehensive range of benefits in addition to incentive programs. The compensation and benefits information set forth in this posting applies to candidates hired in the United States – and this range is specific to Boston and the North-East region of the United States. Candidates hired outside the United States or in a different region of the United States will be eligible for compensation and benefits in accordance with their local market. Orchard is an equal opportunity employer. We recognise and celebrate the diverse culture of our workforce and are committed to creating an inclusive environment for our employees. We fully support the principle of Equality and Diversity in employment and oppose all forms of unlawful or unfair discrimination. We assess all applications on basis of job requirements and individual qualifications. We work within the requirements of all current legislation and we implement the provisions of regulatory codes of practice in employment. Notice to All Applicants: Orchard Therapeutics participates in E-Verify RECRUITERS All employment offers and CV’s are managed through our Human Resources Department and all candidates are presented through this avenue. Therefore, the Human Resources Department at Orchard Therapeutics requests that recruiters are not to contact Orchard Therapeutics employees directly to present candidates. Complying with this request will be a factor in determining future professional relationships with Orchard Therapeutics. Orchard Therapeutics will not accept unsolicited resumes from any source other than directly from candidates for either current or future positions. Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the recruiter does not create any implied obligation on the part of Orchard Therapeutics.

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